The American Urological Association encourages men in good health to have annual PSA testing starting at age 50, or at age 40 if they're in high-risk groups, such as black men or those with a father, brother or son with the disease.
The American Cancer Society, on the other hand, recommends that doctors offer the tests to men age 50 and older who expect to live another 10 years, and test men at high risk if they're age 45 and older. Both groups also suggest that a DRE be done in conjunction with the PSA test.
Though the DRE doesn't help find prostate cancer as well as does the PSA test, it can sometimes help find cancers in men with normal PSA levels.