Histopathology report goes as under:
Low to intermediate grade spindle cell sarcoma, showing focal necrosis. Mitotic count is 2-3/10 HPF. Immunohistochemistry results: Tumour cells are negative for CD-34 and S-100 protein. Suggested histogenetic type probably leiomyosarcoma. This is the report issued by a Renowned Cancer Institute. The patient was having a lump in the thigh which was operated. The Histopath report was done after the operation. My question is... How serious is this? What is the treatment the patient has to undergo from now on?
Take a look at the websites below for more information. I can decode some of that for you. I can't tell you how serious it is...you need to find a doctor who will talk to you and explain things.
Leiomyosarcoma is a rare cancer that affects smooth muscles. Low to intermediate grade is not as bad as advanced, so that part sounds positive. Focal necrosis means there is a part of the tissue sample that shows cells that are dying. I can't tell you what that means in the overall picture. The mitotic count is a measure of how many cells in the sample are dividing. HPF means high power field. I'm taking this to mean that when they looked under a high power microscope, 2-3 out of 10 cells were dividing. I can't give you a reference number for what is normal, but in general, more cells dividing would indicate the tumor is growing faster than a low number.
Immunohistochemistry means staining the cells in the sample with markers to see what kind of cells they are. CD34 is a marker for undifferentiated cells. S-100 is another marker, but I can't tell you exactly what it indicates. The presence or absence of markers can mean either good or bad news, but I don't know exactly how these are used here and I don't want to guess.
That doesn't really answer your questions, because you really need a doctor who knows this case to tell you what to expect. I hope that makes it a little less mysterious, but I'm afraid it's not much help. It makes me sad to think that someone would just hand you this report and not give you some help in understanding what is going on. Sometimes hospitals have a social worker who is there to translate the medical jargon into things you really want and need to know. Ask if there is someone like this. I hope it's a good outcome. Good luck.